ELIXIR CZ Friday Coffee 2021 – EnzymeMiner & SoluProt: mining of soluble enzymes

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EnzymeMiner & SoluProt: mining of soluble enzymes

Jiří Hon from ICRC

We present two integrated bioinformatics tools EnzymeMiner and SoluProt for mining and rational selection of novel soluble enzymes. EnzymeMiner uses one or more enzyme sequences and a description of essential residues to find enzyme family members among millions of uncharacterized protein sequences in the NCBI nr database. SoluProt is a machine-learning method for prediction of soluble protein expression in E. coli integrated in EnzymeMiner for prioritization of search hits. EnzymeMiner and SoluProt help to identify novel putative enzymes and facilitate selection of several expressible targets for experimental characterization. These novel enzymes might have successful applications in biosynthetic pathways for the ecological production or degradation of chemical compounds.

Meet us online every friday morning to explore the portfolio of ELIXIR CZ tools and services at https://global.gotomeeting.com/join/508817845 .

Registration is not needed

Future webinars

11. 6. at 9:30 – IRESs, IRESite and HCVIVdb.
18. 6. at 9:30 – CaverDock: Analysis of Ligand Transport through Protein Tunnels.
25. 6. at 9:30 – PrankWeb.

Take a look at the webinar and give us your feedback

Please note that online session will be recorded and may be used on ELIXIR CZ website, social media, in ELIXIR CZ e-publications and any other ELIXIR CZ online materials.

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